教师个人信息表
姓名 王坚毅 性别
本人照片
出生年月   政治面貌
籍贯 广西浦北 职称 教授
学历 研究生 学位 博士
联系电话 邮政编码 530004
Email jianyiwang208@163.com
QQ 微信
通讯地址 广西南宁市大学东路100号
所在学院 化学化工学院 导师类型 校内导师
导师类别 博士后合作导师, 博士研究生导师, 硕士研究生导师
指导学科一
门类:理学 一级学科:化学 二级学科:有机化学
指导学科二
门类:工学 一级学科:化学工程与技术 二级学科:制药工程
学习和工作经历 王坚毅,男,1974年11月生,客家人,博士,教授,博士生导师,留学回国人员。2006年毕业于南京大学化学化工学院,获理学博士学位;2006-2008于日本京都大学化学研究所从事药物设计方向的博士后研究;2013年9月—2014年1月在中科院上海有机化学研究所从事海星皂甙衍生物全合成的访问研究;2009至今为广西大学化学化工学院教师,制药工程系副主任。研究方向: 肝癌探针、肝靶向抗肿瘤化合物的设计合成,化学生物学, 物理有机化学。现主持国家自然科学基金1项,教育部重点项目1项,广西自然科学基金重点项目1项;参与国家自然科学基金2项。以第一作者或通讯作者在Chem. Sci., Chem. Eur. J., J. Org. Chem., J. Chem. Inf. Model., J. Phys. Chem. B, J. Phys. Chem. A, J. Organomet. Chem., J. Phys. Org. Chem.等国内外杂志发表相关学术论文30多篇。
热忱欢迎相关专业优秀的本科生、研究生来攻读硕士/博士学位或从事毕业设计。
学术兼职 J. Am. Chem. Soc., Chem. Sci., Chem. Comm., Organometallics, Phys. Chem. Chem. Phys., Org. Bio. Chem., Org. Chem. Fron. 等杂志审稿人。
中国化学会员
主讲课程 药物化学
高等药物化学
新药设计与开发
主要研究方向 1.肝癌探针、肝靶向药物设计与合成 2.物理有机化学 3. 化学生物学
主持(或参与)的主要科研项目 1 源于广西莪术的β-榄香烯的肝靶向抗肿瘤化合物的设计、合成与生物学评价
2 乳糖基小分子肝靶化合物的设计、合成物的设计、合成及生物学评价
3 基于β-榄香烯的肝癌治疗剂的设计与合成
4 兼治动脉粥样硬化的降糖化合物设计、合成及机制研究
5 磺酰脲类降糖化合物的设计、合成及分子机理研究
6 松香基多杂环生物活性化合物的合成及构效关系研究
7 基于枞酸等萜烯的光诱导环加成反应构建含张力小环多环体系的立体选择性调控研究
8 基于NHS-Diazirine 的光点击化学对松香基天然活性萜烯分子改性研究
9 中草药忍冬有效成分绿原酸高效分离新工艺一液液萃取分离纯化方法研究
取得的主要成果 2017
1) Feiyang Liu, Piaoping Tang, Ruihua Ding, Lujuan Liao, Lisheng Wang, Mian Wang* and Jianyi Wang* A glycosylation strategy to develop low toxic naphthalimide fluorescent probe for the detection of Fe3+ in aqueous medium, Dalton Transactions, 2017, 46,7515-7522 (IF 4.18,SCI 二区)
2) Jianyi Wang, Qing Chen, Cheng Zhong and Mian Wang, The opening/closure of P-loop and hinge of BCR-ABL1 decodes the low/high bioactivities of dasatinib and axitinib, Phys. Chem. Chem. Phys., 2017, 19, 22444-22453 (IF 4.12,SCI 二区)
3) Wang Mian,Zhou Shuilian,Chen Qing,Wang Lisheng,Liang Zhiqun*,Wang Jianyi*, Understanding the molecular mechanism for the differential inhibitory activities of compounds against MTH1,Sci. Rep.,2017,DOI: 10.1038/srep40557 (IF 4.2, SCI 二区)
4) Cuicui Jiang, Mian Wang, Yanxiu Wang, Xiuneng Tang, Yamin Zhang, Hui Zhang, Lin Ma, Jianyi Wang*,Synthesis and evaluation of two novel rhodamine-based fluorescence probes for specific recognition of Fe3+ ion,Tetrahedron Letters,2017,58,2560-2565 (IF 2.3,SCI 三区)
5) Wang Lisheng,Wu Yi,Liu Yang,Yang Hua,Liu Xu, Li Xiaoxun, Wang Jianyi,Jiang Jun,Copper-Catalyzed P−H Insertions of α‑Imino Carbenes for the Preparation of 3‑Phosphinoylindoles,Organic Letters,2017,19(4), 782~785 (IF 6.7, SCI 一区,Top)
6) Huang Yiran,Zhong Cheng,Lin Hai Xiang,Wang Jianyi, A Method for Finding Metabolic Pathways Using Atomic Group Tracking,Plos One,2017,12(1),e0168725 (IF 3.0,SCI 三区)

2016
7) Zhengjun Chen, Wei Hu, Mian Wang, Lisheng Wang, Guifa Su, Jianyi Wang*. Synthesis and evaluation of a water-solubility glycosyl-rhodamine fluorescent probe detecting Hg2+. Carbohydrate Research, 2016, 429, 81-86 (IF 1.9)
8) Shuilian Zhou, Mian Wang, Zhangfa Tong*, Jianyi Wang*,The Recognition Mechanism of Crizotinib on MTH1: Influence of Chirality on the Bioactivity, Mol. Phys.2016 , 114(16-17), 2364-2372 (IF 1.8, SCI 三区)
9) Lichuan Wu, Shuaibing Liu, Jinrui Wei, Dong Li, Xu Liu, Jianyi Wang, Lisheng Wang, Synthesis and biological evaluation of matrine derivatives as anti-hepatocellular cancer agents, Bioorganic & Medicinal Chemistry Letters, 2016, 26, 4267–4271 (IF 2.5,SCI 三区)
10) Richard Kleingeld, Jianyi Wang, Matthias Lein, Buckminster fullerene adhesion on graphene flakes: Numerical accuracy of dispersion corrected DFT, Polyhedron, 2016, 114, 110-117 (IF 2.1,SCI 三区)
11) Zhang Yan,Tian Yan,Xiang Pei,Huang Ning,Wang Jianyi,Xu Jian-Hua,Zhang Min,A metal-free one-pot synthesis of benzo[c]chromen-6-ones from 3,4-dichlorocoumarins and butadienes using tandem photo-thermal-photo reactions,Organic and Biomolecular Chemistry,2016,14(41), 9874~9882 (IF 3.6, SCI 二区)
12) Sheng Liu ,Yubin Li,Wanxing Wei,Kuiwu Wang,Lisheng Wang,Jianyi Wang,Design, synthesis, molecular docking studies and anti-HBV activity of phenylpropanoid derivatives,Chemico-Biological Interactions,2016,251, 1~9 (IF 2.6, SCI 三区)

2015
13) Xuesong Wu, Mian Wang, Guangwu Zhang, Yan Zhao, Jianyi Wang* and Haibo Ge*, Copper-Catalyzed Diastereoselective Aerobic Intramolecular Dehydrogenative Cyclization of Hydrazones via sp3 C−H Functionalization, Chem. Sci., 2015, 6, 5882-5890 (IF 9.2, SCI 一区,Top)
14) Mian Wang, Hao Luo, Min Zhang and Jianyi Wang*, Why trans- or cis-Dimethyl Fumarate Addition to 2,5-Dimethylpyrrole Gives Exclusively trans-7-Azanorbornane, J. Phys. Chem. A, 2015, 119, 6563-73 (IF 2.8, SCI 三区)
15) Mian Wang, Hao Luo, Lisheng Wang, Jianyi Wang*,What factors cause the complete substrate-controlled selectivity in Rh2(Piv)4-catalyzed cycloadditions of 1,2,3-triazoles with isocyanates or isothiocyanates, J. Organomet. Chem. 2015, 788, 58-67 (IF 2.3, SCI 三区)
16) Xueqiu Huang, Mian Wang, Lisheng Wang, Jianyi Wang*, How rhodium (III) complexes catalyze alkenylation of C(sp3)-H bond of 8-methyquinolines, J. Organomet. Chem. 2015, 787, 1-7 (IF 2.3,SCI 三区)

2014
17) Mian Wang, Marc Baaden, Jianyi Wang*, Zhiqun Liang,A Cooperative Mechanism of Clotrimazoles in P450 revealed by the Dissociation Picture of Clotrimazole from P450,J. Chem. Inf. Model.,2014,54, 1218−1225 (IF 3.7, SCI 二区,Top)
18) Chuanan Liao, Jianyi Wang*, Bin Li*,Mechanism of Mo-catalyzed C-S Cleavage of Thiophene, J. Organomet. Chem., 2014, 749,275-286 (IF 2.3, SCI 三区)

2013
19) Wenhao Sheng, Mian Wang, Matthias Lein, Linbin Jiang, Wanxing Wei, Jianyi Wang*, Mechanism of Cu(I)-catalyzed allylic alkylation of phosphorothioate esters: influence of the leaving group on α-regioselectivity, Chem. Eur. J., 2013,19, 14126–14142 (IF 5.8, SCI 二区)
20) Jingxi Wu, Mian Wang, Lisheng Wang, Jianyi Wang*, Linbin Jiang, How the bicyclo[4.1.0] substrate isomerizes into 4,5-dihydrobenzo[b]furan: the contribution from W(CO)5 and NEt3, J. Org. Chem,2013, 78, 10812-10820 (IF 4.8, SCI 二区, Top)
21) Jianyi Wang*, Dinglong Cai, Min Zhang, Mian Wang*. The addition mechanism of TMSCN into N-acetylpyridinum to give 2-cyanoacetylpyridinum: the roles of TpW(NO)(PMe3) and DABCO, J.Organomet. Chem., 2013, 724, 117–128 (IF 2.3, SCI 三区)
22) Xuetang Xu , Xianli Ma, Wengui Duan, Li Chen, Bo Cen, Qijin Mo and Jianyi Wang. Synthesis and fungicidal activity of dehydroabietyl-1,2,4-triazolo-thiazolidinones, Holzforschung, 2013,67, 107–112. (IF 1.7, SCI 三区)

2012
23) Dinglong Cai, Mian Wang, Jianyi Wang*, Wengui Duan. Quantum chemical study on the mechanism of intramolecular cyclization of 2-benzyloxyphenyl trimethylsilyl ketone to give the benzofuran derivatives, J. Phys. Org. Chem., 2012,25, 400–408(IF1.6)
24) Liao Chuanan, Li Bin, Wang Jianyi*, Wang Yipin. Mechanism of Silver(I)-Catalyzed Enantioselective Synthesis of Axially Chiral Allenes Based on Propargylamines, Chin. J. Chem., 2012,30, 951–958 (IF 1.8)
25) Wang Mian, Yang jipeng, Wang Jianyi*, Wang Xiaojuan. Structural effects of L16Q, S20G, and L16Q-S20G mutations on hIAPP: a comparative molecular dynamics study, Chin. J. Chem., 2012, 30, 241–248 (IF 1.8)
26) Mian Wang, Yun Du, Jianyi Wang, Xiaomin Luo, Hualiang Jiang, Naixia Zhang, Yechun Xu. Dynamic behavior of ubiquitin receptor S5a in free and complex with K48-linked diubiquitin. Mol. Simul., 2012,38, 1015–1021. (IF 1.3)
27) Mian Wang, Jianyi Wang*, Conformational changes of the wild-type hIAPP and the S20P mutant in water revealed by molecular dynamics simulations, Adv. Mater. Res., 2012, 396, 1554-1557 (EI)

2012年以前
28) Yin, Yanchun, Wang Mian, Wang Jianyi*, Zhou Longchang, Duan Wengui. Mechanism of Gold(I)–Catalyzed Conia-ene Reaction of β-Ketoesters with Alkynes: A DFT Study,Chin. J. Chem., 2011, 29, 2320–2326(IF 1.8)
29) Jianyi Wang and Shuhua Li, The Catalytic Mechanism of 6-Phosphogluconate Dehydrogenase: A Theoretical Investigation,J. Phys. Chem. B. 2006,110,7029-7035. (IF 3.2, SCI 三区)
30) Jianyi Wang, Hao Dong, Shuhua Li and Hongwu He,Theoretical Study toward Understanding the Catalytic Mechanism of Pyruvate Decarboxylase,J. Phys. Chem. B. 2005, 109, 18664-18672. (IF 3.2, SCI 三区)
31) Jianyi Wang and Shuhua Li,Theoretical Study toward Understanding the Catalytic Mechanism of Pyruvate Dehydrogenase Multienzeme Complex E1 Component, J. Theor. Comput. Chem. 2006, 5, 447-459. (IF 1.0)
数据更新日期 2017-09-22 填报责任人 王坚毅
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