教师个人信息表
姓名 王勉 性别
本人照片
出生年月   政治面貌 中共党员
籍贯 广西玉林 职称 副教授
学历 研究生 学位
联系电话 邮政编码 530004
Email mianwang23@163.com
QQ 微信
通讯地址 广西南宁市大学东路100号
所在学院 生命科学与技术学院 导师类型 校内导师
导师类别 硕士研究生导师
指导学科一
指导学科二
学习和工作经历 王勉,女,硕士研究生导师,广西大学生命科学与技术学院教师
本科、硕士毕业于中国药科大学
2009年7月至今在广西大学工作
2011年 中国科学院上海药物所新药设计与发现中心,生物大分子结构和功能及药物设计的课题研究
2015年-2016年 哈佛大学医学院,抗肿瘤化合物评价、肿瘤细胞/干细胞3D培养及3D打印的博士课题研究

学术兼职
主讲课程 1.药剂学
2.药学分子生物学
主要研究方向 (1)抗肿瘤前药/抗肿瘤药物传递系统的构建、生物评价及作用机制研究
(2)化学生物学
主持(或参与)的主要科研项目 1 基于β-榄香烯的肝癌治疗剂的设计与合成
2 乳糖基小分子肝靶化合物的设计、合成物的设计、合成及生物学评价
3 糖缀杂环肝靶向化学载体的设计与合成
4 基于NHS-Diazirine 的光点击化学对松香基天然活性萜烯分子改性研究
5 源于广西莪术的β-榄香烯的肝靶向抗肿瘤化合物的设计、合成与生物学评价
取得的主要成果 1) Feiyang Liu,Piaoping Tang, Ruihua Ding, Lujuan Liao, Lisheng Wang,Mian Wang*,Jianyi Wang*. A glycosylation strategy to develop a low toxic naphthalimide fluorescent probe for the detection of Fe3+ in aqueous medium. Dalton Trans., 2017,46,7515–7522. (SCI 二区)
2) Jianyi Wang, Qing Chen, Mian Wang*, Cheng Zhong. The opening/closure of the P-loop and hinge of BCR-ABL1 decodes the low/high bioactivities of dasatinib and axitinib. Phys. Chem. Chem. Phys., 2017,19,22444--22453.(SCI 二区)
3) Mian Wang, Marc Baaden, Zhiqun Liang*, Jianyi Wang*. A Cooperative Mechanism of Clotrimazoles in P450 revealed by the Dissociation Picture of Clotrimazole from P450. Journal of Chemical Information and Modeling, 2014,54,1218-1225. (SCI 二区,Top)
4) Mian Wang, Shuilian Zhou, Qing Chen, Lisheng Wang, Zhiqun Liang* & Jianyi Wang*, Understanding the molecular mechanism for the differential inhibitory activities of compounds against MTH1, Scientific Reports,2017,DOI: 10.1038/srep40557(SCI 二区)
5) Wenhao Sheng, Mian Wang, Matthias Lein, Linbin Jiang, Wanxing Wei, Jianyi Wang*. Mechanism of Copper(I)-Catalyzed Allylic Alkylation of Phosphorothioate Esters: Influence of the Leaving Group on α Regioselectivity. Chemistry: A European journal 2013,19,14126–14142. (co-first author)(SCI 二区)
6) Xuesong Wu, Mian Wang, Guangwu Zhang,Yan Zhao, Jianyi Wang and Haibo Ge. Copper-Catalyzed Diastereoselective Aerobic Intramolecular Dehydrogenative Cyclization of Hydrazones via sp3 C−H Functionalization. Chem. Sci., 2015,6,5882-5890.(SCI 一区,top)
7) Jingxi Wu, Mian Wang, Lisheng Wang, Jianyi Wang*, Linbin Jiang*. How the bicyclo[4.1.0] substrate isomerizes into 4, 5-dihydrobenzo[b]furan: the contribution from W(CO)5 and NEt3. The Journal of Organic Chemistry 2013,78,10812-10820.(SCI 二区,top)
8) Jingzhou Yang*, Yu Shrike Zhang*, Pengfei Lei, Xiaozhi Hu, Mian Wang, Haitao Liu, Xiulin Shen, Kun Li, Zhaohui Huang, Juntong Huang, Jie Ju, Yihe Hu*, and Ali Khademhosseini*. “Steel–Concrete” Inspired Biofunctional Layered Hybrid Cage for Spine Fusion and Segmental Bone Reconstruction. ACS Biomaterials Science & Engineering. 2017, 3,637-647. (SCI )
9) Mian Wang, Hao Luo, Min Zhang, and Jianyi Wang. Why trans- or cis-Dimethyl Fumarate Addition to 2,5-Dimethylpyrrole Gives Exclusively trans-7-Azanorbornane. J. Phys. Chem. A, 2015,119,6563-73.(SCI )
10) Mian Wang, Hao Luo, Lisheng Wang, Jianyi Wang. What factors cause the complete substrate-controlled selectivity in Rh2(Piv)4-catalyzed cycloadditions of 1,2,3-triazoles with isocyanates or isothiocyanates. J. Organomet. Chem. 2015,788,58-67.(SCI )
11) Jianyi Wang*, Dinglong Cai, Min Zhang, Mian Wang*. The addition mechanism of TMSCN into N-acetylpyridinum to give 2-cyanoacetylpyridinum: the roles of TpW(NO)(PMe3) and DABCO. Journal of Organometallic Chemistry. 2013,724,117-128.(SCI )
12) Cuicui Jiang, Mian Wang, Yanxiu Wang, Xiuneng Tang, Yamin Zhang, Hui Zhang, Lin Ma, Jianyi Wang*. Synthesis and evaluation of two novel rhodamine-based fluorescence probes for specific recognition of Fe3+ ion. Tetrahedron Letters. 2017,58,2560-2565.(SCI )
13) Shuilian Zhou, Mian Wang, Zhangfa Tong*, Jianyi Wang*. The recognition mechanism of crizotinib on MTH1: influence of chirality on the bioactivity. Molecular Physics, 2016,114,2364-2372.(SCI )
14) Mian Wang, Yun Du, Jianyi Wang, Xiaomin Luo, Hualiang Jiang, Naixia Zhang*, Yechun Xu*. Dynamic behavior of ubiquitin receptor S5a in free and complex with K48-linked diubiquitin. Molecular Simulation 2012,38,1015–1021.(SCI )
15) Mian Wang, Jipeng Yang, Jianyi Wang*, Xiaojuan Wang. Structural effects of L16Q, S20G, and L16Q-S20G mutations on hIAPP: a comparative molecular dynamics study. Chinese Journal of Chemistry 2012,30,241–248.(SCI )
16) Zhengjun Chen, Wei Hu, Mian Wang, Lisheng Wang, Guifa Su, Jianyi Wang*. Synthesis and evaluation of a water-solubility glycosyl-rhodamine fluorescent probe detecting Hg2+. Carbohydrate Research. 2016,429,81-86.(SCI )
17) Mian Wang, Jianyi Wang*. Conformational changes of the wild-type hIAPP and the S20P mutant in water revealed by molecular dynamics simulations. Advanced Materials Research 2012,396-398,1554-1557.
18) Dinglong Cai, Mian Wang, Jianyi Wang*, Wengui Duan. DFT study on the mechanism of intramolecular cyclization of 2-benzyloxyphenyl trimethylsilyl ketone to give the benzofuran derivatives. Journal of Physical organic Chemistry 2011,25,400-408.(SCI )
19) Yanchun Yin, Mian Wang, Jianyi Wang*, et al. Mechanism of Gold(Ι)-Catalyzed Conia-ene Reaction of β-Ketoesters with Alkynes: A DFT Study. Chinese Journal of Chemistry 2011, 29, 2320-2326.(SCI )
20) Jianyi Wang, Mian Wang. Molecular Dynamics Simulations in Pharmaceutics. Chinese Journal of Pharmaceuticals (Chinese edition) 2010,41,863-868.
21) Mian Wang, Jiabi Zhu, Yue Tang. Advances in pulmonary delivery systems. Chinese Journal of New Drugs (Chinese edition) 2009,18,694-698.





数据更新日期 2017-09-30 填报责任人 王勉
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